Ko nga Kairangahau mai i te Tari Hangarau me te Aerospace Engineering (MAE) o te Kura Hangarau o Herbert Wertheim kua whakawhanakehia he momo hou o te kiriuhi hemodialysis i hangaia mai i te graphene oxide (GO), he papanga paparanga monoatomic.Ko te tumanako ka whakarereke katoa i te maimoatanga o te mate whakaheke whatukuhu ma te manawanui.Ma tenei ahunga whakamua ka taea e te microchip dialyzer te piri ki te kiri o te turoro.Ma te mahi i raro i te pehanga toto, ka whakakorehia te papu toto me te ara iahiko toto extracorporeal, ka taea te whakamaarama i roto i te whakamarie o to kaainga.Ka whakatauritea ki te kiriuhi polymer o naianei, ko te uruhanga o te kiriuhi e rua ota teitei ake, he hototahi toto, a ehara i te mea ngawari ki te tauine rite ki nga kiriuhi polymer.
Ko Ahorangi Knox T. Millsaps o MAE me te kairangahau matua o te kaupapa membrane a Saeed Moghaddam me tana roopu kua whakawhanakehia he tukanga hou e pa ana ki te whakahiato-whaiaro me te arotautanga o nga ahuatanga tinana me te matū o GO nanoplatelets.Ko tenei mahi ka huri noa i nga paparanga 3 GO ki roto i nga huihuinga nanosheet kua tino whakaritea, na reira ka eke ki te kaha teitei me te whiriwhiringa."Na roto i te whakawhanake i te kiriuhi e tino pai ake ana i tana tauira koiora, te glomerular basement membrane (GBM) o te whatukuhu, kua whakaatuhia e matou te kaha nui o te nanomaterials, te nanoengineering, me te whakahiato-whaiaro molecular."Mogda Dr. Mu ka mea.
Ko te rangahau mo te mahi membrane i roto i nga ahuatanga hemodialysis kua puta nga hua tino whakatenatena.Ko te whakarea tatari o te Urea me te cytochrome-c he 0.5 me te 0.4, e ranea ana mo te whakamaarama puhoi mo te wa roa me te pupuri neke atu i te 99% o te albumin;Ko nga rangahau e pa ana ki te hemolysis, ki te whakakii i te whakahohe me te coagulation kua kitea he rite ki nga rauemi kiriuhi dialysis o naianei, he pai ake ranei i te mahi o nga rauemi kiriuhi dialysis o naianei.Ko nga hua o tenei rangahau kua whakaputaina i runga i nga Atanga Rawa Ake (February 5, 2021) i raro i te taitara "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
I kii a Dr. Moghaddam: "Kua whakaatuhia e matou he GO nanoplatelet motuhake kua oti te whakarite mosaic, e tino ahu whakamua ana i nga mahi tekau tau ki te whakawhanaketanga o nga kiriuhi i runga i te graphene."He turanga pai tenei ka taea te whakapai ake i te whakaheke toto i te po i te kainga.I tenei wa kei te mahi a Takuta Moghaddam ki te hanga miihini miihini ma te whakamahi i nga kiriuhi GO hou, e tata ai te rangahau ki te pono o te whakarato i nga taputapu hemodialysis e mau ana mo nga turoro mate whatukuhu.
Te faataa ra te vea a Nature (Maehe 2020) e: “Te mana‘o ra te Faanahonahoraa no te oraora-maitai-raa o te ao nei e fatata 1.2 mirioni taata e pohe nei i te ma‘i roro uira i te mau matahiti atoa na te ao nei [e te mau ma‘i renal i te pae hopea (ESRD) no te ma‘i ma‘i ma‘i e te toto teitei]…Te whakamaaramatanga Ko te whakakotahitanga o nga herenga mahi o te hangarau me te utu te tikanga he iti iho i te haurua o te hunga e matea ana ki te rongoa ka uru atu ki a raatau."Ko nga taputapu kaahua iti e tika ana he otinga ohaoha hei whakapiki i nga reiti oranga, ina koa i te whanaketanga o Haina."Ko to tatou membrane he waahanga nui o te punaha kakahu iti, ka taea te whakaputa i te mahi filtration o te whatukuhu, te whakapai ake i te whakamarie me te utu o te ao," e kii ana a Dr. Moghaddam.
"Ko nga ahunga whakamua nui i roto i te maimoatanga o nga turoro me te hemodialysis me te ngoikore o te whatukuhu he iti noa na te hangarau membrane.Ko te hangarau membrane kaore i tino ahu whakamua i roto i nga tekau tau kua hipa.Ko te ahunga whakamua matua o te hangarau membrane me whakapai ake i te renal dialysis.Ko nga Rauemi tino kaha me te kowhiria, penei i te kiriuhi graphene oxide tino kikokore i whakawhanakehia i konei, ka huri pea i te tauira.Kaore e taea e nga kiriuhi puhoi tino angiangi te mohio ki nga dialyzers iti, engari ano hoki nga taputapu kawe me te mau kakahu, na reira ka whakapai ake i te kounga o te ora me te mate turoro.I kii a James L. McGrath he ahorangi ia mo te hangarau koiora i te Whare Wananga o Rochester me te kaitoha-tahi o te hangarau kirikiri kirikiri ultra-aniangi hou mo nga momo tono koiora (Nature, 2007).
I whakawhiwhia tenei rangahau e te National Institute of Biomedical Imaging and Bioengineering (NIBIB) i raro i te National Institutes of Health.Kei roto i te roopu a Takuta Moghaddam ko Takuta Richard P. Rode, he hoa whai muri i te UF MAE, ko Takuta Thomas R. Gaborski (te kaititiro-tumuaki), ko Daniel Ornt, MD (he kaitirotiro tuarua-tumuaki), me Henry C o te Tari Biomedical. Hangarau, Rochester Institute of Technology.Dr. Chung raua ko Hayley N. Miller.
Ko Dr Moghaddam he mema o te UF Interdisciplinary Microsystems Group me te arahi i te Nanostructured Energy Systems Laboratory (NESLabs), ko tana kaupapa ko te whakapai ake i te taumata matauranga o te nanoengineering o nga hanganga porous mahi me te ahupūngao whakawhiti moroiti / nanoscale.Ka whakahiatohia e ia nga marautanga maha o te miihini me te putaiao kia pai ake ai te maarama ki te ahupūngao o te tuku moroiti/nano-tauine me te whakawhanake i nga hanganga whakatipuranga me nga punaha he pai ake te mahi me te pai.
Herbert Wertheim College of Engineering 300 Weil Hall Pouaka Pouaka 116550 Gainesville, FL 32611-6550 Nama waea tari